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A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN

Identifieur interne : 000070 ( France/Analysis ); précédent : 000069; suivant : 000071

A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN

Auteurs : Gyungah Jun [États-Unis] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Maria Vronskaya [Royaume-Uni] ; Jean-Charles Lambert [France] ; Jaeyoon Chung [États-Unis] ; Adam C. Naj [États-Unis] ; Brian W. Kunkle [États-Unis] ; Li-San Wang [États-Unis] ; Joshua C. Bis [États-Unis] ; Céline Bellenguez [France] ; Denise Harold [Irlande (pays)] ; Kathryn L. Lunetta [États-Unis] ; Anita L. Destefano [États-Unis] ; Benjamin Grenier-Boley [France] ; Rebecca Sims [Royaume-Uni] ; Gary W. Beecham [États-Unis] ; Albert V. Smith [Islande] ; Vincent Chouraki [États-Unis] ; Kara L. Hamilton-Nelson [États-Unis] ; M. Arfan Ikram [Pays-Bas] ; Nathalie Fievet [France] ; Nicola Denning [Royaume-Uni] ; Eden R. Martin [États-Unis] ; Helena Schmidt [Autriche] ; Yochiro Kamatani [Japon, France] ; Melanie L. Dunstan [Royaume-Uni] ; Otto Valladares [États-Unis] ; Agustin Ruiz Laza [Espagne] ; Diana Zelenika ; Alfredo Ramirez [Allemagne] ; Tatiana M. Foroud [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Anne Boland [France] ; Tim Becker [Allemagne] ; Walter A. Kukull [États-Unis] ; Sven J. Van Der Lee [Pays-Bas] ; Florence Pasquier [France] ; Carlos Cruchaga [États-Unis] ; Duane Beekly [États-Unis] ; Annette L. Fitzpatrick [États-Unis] ; Oliver Hanon [France] ; Michael Gill [Irlande (pays)] ; Robert Barber [États-Unis] ; Vilmundur Gudnason [Islande] ; Dominique Campion [France] ; Seth Love [Royaume-Uni] ; David A. Bennett [États-Unis] ; Najaf Amin [Pays-Bas] ; Claudine Berr [France] ; Magda Tsolaki [Grèce] ; Joseph D. Buxbaum [États-Unis] ; Oscar L. Lopez [États-Unis] ; Vincent Deramecourt [France] ; Nick C. Fox [Royaume-Uni] ; Laura B. Cantwell [États-Unis] ; Lluis Tárraga [Espagne] ; Carole Dufouil [France] ; John Hardy [Royaume-Uni] ; Paul K. Crane [États-Unis] ; Gudny Eiriksdottir [Islande] ; Didier Hannequin [France] ; Robert Clarke [Royaume-Uni] ; Denis Evans [États-Unis] ; Thomas H. Mosley [États-Unis] ; Luc Letenneur [France] ; Carol Brayne [Royaume-Uni] ; Wolfgang Maier [Allemagne] ; Philip De Jager [États-Unis, Pays-Bas] ; Valur Emilsson [Islande] ; Jean-François Dartigues [France] ; Harald Hampel [Allemagne] ; M. Ilyas Kamboh [États-Unis] ; Renee F. A. G. De Bruijn [Pays-Bas] ; Christophe Tzourio [France] ; Pau Pastor [Espagne] ; Eric B. Larson [États-Unis] ; Jerome I. Rotter [États-Unis] ; Michael C. O Onovan [Royaume-Uni] ; Thomas J. Montine [États-Unis] ; Michael A. Nalls [États-Unis] ; Simon Mead [Royaume-Uni] ; Eric M. Reiman [États-Unis] ; Palmi V. Jonsson [Islande] ; Clive Holmes [Royaume-Uni] ; Peter H. St George-Hyslop [Canada, Royaume-Uni] ; Mercè Boada [Espagne] ; Peter Passmore [Royaume-Uni] ; Jens R. Wendland [États-Unis] ; Reinhold Schmidt [Autriche] ; Kevin Morgan [Royaume-Uni] ; Ashley R. Winslow [États-Unis] ; John F. Powell [Royaume-Uni] ; Minerva Carasquillo [États-Unis] ; Steven G. Younkin [États-Unis] ; J Hanna Jakobsd Ttir [Islande] ; John Sk Kauwe [États-Unis] ; Kirk C. Wilhelmsen [États-Unis] ; Dan Rujescu ; Markus M. Nöthen [Allemagne] ; Albert Hofman [Pays-Bas] ; Lesley Jones [Royaume-Uni] ; Jonathan L. Haines [États-Unis] ; Bruce M. Psaty [États-Unis] ; Christine Van Broeckhoven [Belgique] ; Peter Holmans [Royaume-Uni] ; Lenore J. Launer [États-Unis] ; Richard Mayeux [États-Unis] ; Mark Lathrop [France, Canada] ; Alison M. Goate [États-Unis] ; Valentina Escott-Price [Royaume-Uni] ; Sudha Seshadri [États-Unis] ; Margaret A. Pericak-Vance [États-Unis] ; Philippe Amouyel [France] ; Julie Williams [Royaume-Uni] ; Cornelia M. Van Duijn [Pays-Bas] ; Gerard D. Schellenberg [États-Unis] ; Lindsay A. Farrer [États-Unis]

Source :

RBID : PMC:4573764

Abstract

APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4+ (10,352 cases and 9,207 controls) and APOE ε4− (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and APOE ε4 status. Suggestive associations (P<1x10−4) in stage 1 were evaluated in an independent sample (stage 2) containing 4,203 subjects (APOE ε4+: 1,250 cases and 536 controls; APOE ε4-: 718 cases and 1,699 controls). Among APOE ε4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KANSL1 and LRRC37A on chromosome 17 near MAPT) in a meta-analysis of the stage 1 and stage 2 datasets (best SNP, rs2732703, P=5·8x10−9). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100 kilobase region that includes MAPT. Except for previously identified AD loci showing stronger association in APOE ε4+ subjects (CR1 and CLU) or APOE ε4− subjects (MS4A6A/MS4A4A/ MS4A6E), no other SNPs were significantly associated with AD in a specific APOE genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with rs1595014 in TMEM106B (P=1·6x10−7) is noteworthy because TMEM106B variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four KANSL1 probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3x10−8), frontal cortex (P≤1.3x10−9), and temporal cortex (P≤1.2x10−11). Rs113986870 is also strongly associated with a MAPT probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2x10−6) and temporal cortex (P=2.6x10−6). Our APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking APOE ε4 compared to persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted.


Url:
DOI: 10.1038/mp.2015.23
PubMed: 25778476
PubMed Central: 4573764


Affiliations:

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PMC:4573764

Le document en format XML

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<name sortKey="Chung, Jaeyoon" sort="Chung, Jaeyoon" uniqKey="Chung J" first="Jaeyoon" last="Chung">Jaeyoon Chung</name>
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<name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name>
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<name sortKey="Kunkle, Brian W" sort="Kunkle, Brian W" uniqKey="Kunkle B" first="Brian W." last="Kunkle">Brian W. Kunkle</name>
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<name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name>
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<name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name>
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<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
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<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
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<name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name>
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<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
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<name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name>
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<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
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<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
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<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
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<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
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<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
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<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
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<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
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<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
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<name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name>
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<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
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<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
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<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
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<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
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<nlm:aff id="A18">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<affiliation wicri:level="3">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kamatani, Yochiro" sort="Kamatani, Yochiro" uniqKey="Kamatani Y" first="Yochiro" last="Kamatani">Yochiro Kamatani</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa</wicri:regionArea>
<wicri:noRegion>Kanagawa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A22">Foundation Jean Dausset – CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset – CEPH, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Laza, Agustin Ruiz" sort="Laza, Agustin Ruiz" uniqKey="Laza A" first="Agustin Ruiz" last="Laza">Agustin Ruiz Laza</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
</author>
<author>
<name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name>
<affiliation wicri:level="3">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<affiliation wicri:level="1">
<nlm:aff id="A27">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN</wicri:regionArea>
<wicri:noRegion>IN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<affiliation wicri:level="3">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A29">Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name>
<affiliation wicri:level="4">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name>
<affiliation wicri:level="4">
<nlm:aff id="A34">National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hanon, Oliver" sort="Hanon, Oliver" uniqKey="Hanon O" first="Oliver" last="Hanon">Oliver Hanon</name>
<affiliation wicri:level="1">
<nlm:aff id="A36">University Paris Descartes, Sorbonne Paris V, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Sorbonne Paris V</wicri:regionArea>
<wicri:noRegion>Sorbonne Paris V</wicri:noRegion>
<wicri:noRegion>Sorbonne Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A37">Broca Hospital, Geriatrics Department, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Broca Hospital, Geriatrics Department, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name>
<affiliation wicri:level="1">
<nlm:aff id="A38">Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Barber, Robert" sort="Barber, Robert" uniqKey="Barber R" first="Robert" last="Barber">Robert Barber</name>
<affiliation wicri:level="1">
<nlm:aff id="A39">Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<affiliation wicri:level="3">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
<placeName>
<region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A41">University Hospital, 76031 Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, 76031 Rouen</wicri:regionArea>
<wicri:noRegion>76031 Rouen</wicri:noRegion>
<wicri:noRegion>76031 Rouen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name>
<affiliation wicri:level="1">
<nlm:aff id="A42">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="A43">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A44">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<affiliation wicri:level="3">
<nlm:aff id="A45">Inserm U888, Hôpital La Colombière, Montpellier, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U888, Hôpital La Colombière, Montpellier</wicri:regionArea>
<placeName>
<region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation wicri:level="1">
<nlm:aff id="A46">Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<affiliation wicri:level="1">
<nlm:aff id="A47">Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
<wicri:noRegion>NY</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
<wicri:noRegion>NY</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A49">Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
<wicri:noRegion>NY</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A51">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<affiliation wicri:level="3">
<nlm:aff id="A52">Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluis" last="Tárraga">Lluis Tárraga</name>
<affiliation wicri:level="3">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="3">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A56">Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name>
<affiliation wicri:level="4">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<affiliation wicri:level="3">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
<placeName>
<region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="4">
<nlm:aff id="A58">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName>
<settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author>
<name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<affiliation wicri:level="1">
<nlm:aff id="A59">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="A60">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<wicri:noRegion>MS</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name>
<affiliation wicri:level="4">
<nlm:aff id="A61">Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="3">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="A62">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A63">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A64">Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A65">Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<affiliation wicri:level="3">
<nlm:aff id="A66">Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Frankfurt, Frankfurt am Main</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A67">Department of Psychiatry, Ludwig Maximilians University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Ludwig Maximilians University, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A68">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName>
<settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<affiliation wicri:level="1">
<nlm:aff id="A69">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A70">CIBERNED, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBERNED, Instituto de Salud Carlos III, Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name>
<affiliation wicri:level="4">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="A72">Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A73">Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="4">
<nlm:aff id="A74">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="1">
<nlm:aff id="A75">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<affiliation wicri:level="3">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<affiliation wicri:level="1">
<nlm:aff id="A76">Arizona Alzheimer’s Consortium, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arizona Alzheimer’s Consortium, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A77">Department of Psychiatry, University of Arizona, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Arizona, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A78">Banner Alzheimer’s Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Banner Alzheimer’s Institute, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A79">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A80">Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Geriatrics, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name>
<affiliation wicri:level="1">
<nlm:aff id="A81">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="St George Hyslop, Peter H" sort="St George Hyslop, Peter H" uniqKey="St George Hyslop P" first="Peter H." last="St George-Hyslop">Peter H. St George-Hyslop</name>
<affiliation wicri:level="4">
<nlm:aff id="A82">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A83">Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<affiliation wicri:level="3">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name>
<affiliation wicri:level="1">
<nlm:aff id="A84">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wendland, Jens R" sort="Wendland, Jens R" uniqKey="Wendland J" first="Jens R." last="Wendland">Jens R. Wendland</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A86">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name>
<affiliation wicri:level="4">
<nlm:aff id="A87">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham</wicri:regionArea>
<orgName type="university">Université de Nottingham</orgName>
<placeName>
<settlement type="city">Nottingham</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Nottinghamshire</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Winslow, Ashley R" sort="Winslow, Ashley R" uniqKey="Winslow A" first="Ashley R." last="Winslow">Ashley R. Winslow</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
<affiliation wicri:level="3">
<nlm:aff id="A88">King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carasquillo, Minerva" sort="Carasquillo, Minerva" uniqKey="Carasquillo M" first="Minerva" last="Carasquillo">Minerva Carasquillo</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jakobsd Ttir, J Hanna" sort="Jakobsd Ttir, J Hanna" uniqKey="Jakobsd Ttir J" first="J Hanna" last="Jakobsd Ttir">J Hanna Jakobsd Ttir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name>
<affiliation wicri:level="2">
<nlm:aff id="A90">Department of Biology, Brigham Young University, Provo, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Brigham Young University, Provo, Utah</wicri:regionArea>
<placeName>
<region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wilhelmsen, Kirk C" sort="Wilhelmsen, Kirk C" uniqKey="Wilhelmsen K" first="Kirk C." last="Wilhelmsen">Kirk C. Wilhelmsen</name>
<affiliation wicri:level="1">
<nlm:aff id="A91">Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<wicri:noRegion>NC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name>
<affiliation>
<nlm:aff id="A92">Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Julius-Kühn-Str. 706112 Halle Germany</nlm:aff>
<wicri:noCountry code="subfield">Julius-Kühn-Str. 706112 Halle Germany</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="3">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A93">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="1">
<nlm:aff id="A94">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea>
<wicri:noRegion>OH</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="4">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1">
<nlm:aff id="A95">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A96">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName>
<settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="A97">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="4">
<nlm:aff id="A98">Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea>
<orgName type="university">Université Columbia</orgName>
<placeName>
<settlement type="city">New York</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A99">Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea>
<orgName type="university">Université Columbia</orgName>
<placeName>
<settlement type="city">New York</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A100">Department of Neurology, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<region type="state">Québec</region>
</placeName>
</affiliation>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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<name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name>
<affiliation wicri:level="4">
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
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<settlement type="city">Saint-Louis (Missouri)</settlement>
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<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
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<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
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<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
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<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
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<affiliation wicri:level="3">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
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<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
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<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
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<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A103">University Hospital, CHRU Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, CHRU Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
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<name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name>
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<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
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</affiliation>
</author>
<author>
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<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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</affiliation>
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<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
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<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
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<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
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<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
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<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A104">Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, MA</wicri:regionArea>
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<title xml:lang="en" level="a" type="main">A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN</title>
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<name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name>
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<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
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<author>
<name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
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<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name>
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<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
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<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="3">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jaeyoon" sort="Chung, Jaeyoon" uniqKey="Chung J" first="Jaeyoon" last="Chung">Jaeyoon Chung</name>
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<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
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</affiliation>
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<author>
<name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
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</author>
<author>
<name sortKey="Kunkle, Brian W" sort="Kunkle, Brian W" uniqKey="Kunkle B" first="Brian W." last="Kunkle">Brian W. Kunkle</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
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<author>
<name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name>
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<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
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<author>
<name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name>
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<nlm:aff id="A13">Trinity College, University of Dublin, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
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<author>
<name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
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<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
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<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
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</author>
<author>
<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
<affiliation wicri:level="3">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A18">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<affiliation wicri:level="3">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kamatani, Yochiro" sort="Kamatani, Yochiro" uniqKey="Kamatani Y" first="Yochiro" last="Kamatani">Yochiro Kamatani</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa</wicri:regionArea>
<wicri:noRegion>Kanagawa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A22">Foundation Jean Dausset – CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset – CEPH, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Laza, Agustin Ruiz" sort="Laza, Agustin Ruiz" uniqKey="Laza A" first="Agustin Ruiz" last="Laza">Agustin Ruiz Laza</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
</author>
<author>
<name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name>
<affiliation wicri:level="3">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<affiliation wicri:level="1">
<nlm:aff id="A27">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN</wicri:regionArea>
<wicri:noRegion>IN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<affiliation wicri:level="3">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A29">Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name>
<affiliation wicri:level="4">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name>
<affiliation wicri:level="4">
<nlm:aff id="A34">National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hanon, Oliver" sort="Hanon, Oliver" uniqKey="Hanon O" first="Oliver" last="Hanon">Oliver Hanon</name>
<affiliation wicri:level="1">
<nlm:aff id="A36">University Paris Descartes, Sorbonne Paris V, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Sorbonne Paris V</wicri:regionArea>
<wicri:noRegion>Sorbonne Paris V</wicri:noRegion>
<wicri:noRegion>Sorbonne Paris V</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A37">Broca Hospital, Geriatrics Department, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Broca Hospital, Geriatrics Department, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name>
<affiliation wicri:level="1">
<nlm:aff id="A38">Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Barber, Robert" sort="Barber, Robert" uniqKey="Barber R" first="Robert" last="Barber">Robert Barber</name>
<affiliation wicri:level="1">
<nlm:aff id="A39">Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<affiliation wicri:level="3">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
<placeName>
<region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A41">University Hospital, 76031 Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, 76031 Rouen</wicri:regionArea>
<wicri:noRegion>76031 Rouen</wicri:noRegion>
<wicri:noRegion>76031 Rouen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name>
<affiliation wicri:level="1">
<nlm:aff id="A42">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="A43">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A44">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<affiliation wicri:level="3">
<nlm:aff id="A45">Inserm U888, Hôpital La Colombière, Montpellier, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U888, Hôpital La Colombière, Montpellier</wicri:regionArea>
<placeName>
<region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation wicri:level="1">
<nlm:aff id="A46">Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<affiliation wicri:level="1">
<nlm:aff id="A47">Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
<wicri:noRegion>NY</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
<wicri:noRegion>NY</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A49">Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
<wicri:noRegion>NY</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A51">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<affiliation wicri:level="3">
<nlm:aff id="A52">Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluis" last="Tárraga">Lluis Tárraga</name>
<affiliation wicri:level="3">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="3">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A56">Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name>
<affiliation wicri:level="4">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<affiliation wicri:level="3">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
<placeName>
<region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="4">
<nlm:aff id="A58">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName>
<settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author>
<name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<affiliation wicri:level="1">
<nlm:aff id="A59">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="A60">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<wicri:noRegion>MS</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name>
<affiliation wicri:level="4">
<nlm:aff id="A61">Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="3">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="A62">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A63">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A64">Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
<wicri:noRegion>33076, Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A65">Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<affiliation wicri:level="3">
<nlm:aff id="A66">Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Frankfurt, Frankfurt am Main</wicri:regionArea>
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<region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A67">Department of Psychiatry, Ludwig Maximilians University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Ludwig Maximilians University, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A68">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName>
<settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
<placeName>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<affiliation wicri:level="1">
<nlm:aff id="A69">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A70">CIBERNED, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBERNED, Instituto de Salud Carlos III, Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name>
<affiliation wicri:level="4">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="A72">Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A73">Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
<wicri:noRegion>CA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="4">
<nlm:aff id="A74">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="1">
<nlm:aff id="A75">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<affiliation wicri:level="3">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<affiliation wicri:level="1">
<nlm:aff id="A76">Arizona Alzheimer’s Consortium, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arizona Alzheimer’s Consortium, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A77">Department of Psychiatry, University of Arizona, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Arizona, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A78">Banner Alzheimer’s Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Banner Alzheimer’s Institute, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A79">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A80">Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Geriatrics, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name>
<affiliation wicri:level="1">
<nlm:aff id="A81">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="St George Hyslop, Peter H" sort="St George Hyslop, Peter H" uniqKey="St George Hyslop P" first="Peter H." last="St George-Hyslop">Peter H. St George-Hyslop</name>
<affiliation wicri:level="4">
<nlm:aff id="A82">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A83">Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<affiliation wicri:level="3">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name>
<affiliation wicri:level="1">
<nlm:aff id="A84">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wendland, Jens R" sort="Wendland, Jens R" uniqKey="Wendland J" first="Jens R." last="Wendland">Jens R. Wendland</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A86">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name>
<affiliation wicri:level="4">
<nlm:aff id="A87">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham</wicri:regionArea>
<orgName type="university">Université de Nottingham</orgName>
<placeName>
<settlement type="city">Nottingham</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Nottinghamshire</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Winslow, Ashley R" sort="Winslow, Ashley R" uniqKey="Winslow A" first="Ashley R." last="Winslow">Ashley R. Winslow</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
<affiliation wicri:level="3">
<nlm:aff id="A88">King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carasquillo, Minerva" sort="Carasquillo, Minerva" uniqKey="Carasquillo M" first="Minerva" last="Carasquillo">Minerva Carasquillo</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jakobsd Ttir, J Hanna" sort="Jakobsd Ttir, J Hanna" uniqKey="Jakobsd Ttir J" first="J Hanna" last="Jakobsd Ttir">J Hanna Jakobsd Ttir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name>
<affiliation wicri:level="2">
<nlm:aff id="A90">Department of Biology, Brigham Young University, Provo, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Brigham Young University, Provo, Utah</wicri:regionArea>
<placeName>
<region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wilhelmsen, Kirk C" sort="Wilhelmsen, Kirk C" uniqKey="Wilhelmsen K" first="Kirk C." last="Wilhelmsen">Kirk C. Wilhelmsen</name>
<affiliation wicri:level="1">
<nlm:aff id="A91">Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<wicri:noRegion>NC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name>
<affiliation>
<nlm:aff id="A92">Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Julius-Kühn-Str. 706112 Halle Germany</nlm:aff>
<wicri:noCountry code="subfield">Julius-Kühn-Str. 706112 Halle Germany</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="3">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A93">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="1">
<nlm:aff id="A94">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea>
<wicri:noRegion>OH</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="4">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName>
<settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1">
<nlm:aff id="A95">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A96">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName>
<settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="A97">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="4">
<nlm:aff id="A98">Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea>
<orgName type="university">Université Columbia</orgName>
<placeName>
<settlement type="city">New York</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A99">Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea>
<orgName type="university">Université Columbia</orgName>
<placeName>
<settlement type="city">New York</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A100">Department of Neurology, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University, New York, NY</wicri:regionArea>
<orgName type="university">Université Columbia</orgName>
<placeName>
<settlement type="city">New York</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A101">McGill University and Génome Québec Innovation Centre, Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea>
<placeName>
<settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A102">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name>
<affiliation wicri:level="4">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName>
<settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A103">University Hospital, CHRU Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, CHRU Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
<wicri:noRegion>PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A104">Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Molecular psychiatry</title>
<idno type="ISSN">1359-4184</idno>
<idno type="eISSN">1476-5578</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p id="P1">
<italic>APOE</italic>
ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in
<italic>APOE</italic>
ε4+ (10,352 cases and 9,207 controls) and
<italic>APOE</italic>
ε4− (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and
<italic>APOE</italic>
ε4 status. Suggestive associations (P<1x10
<sup>−4</sup>
) in stage 1 were evaluated in an independent sample (stage 2) containing 4,203 subjects (
<italic>APOE</italic>
ε4+: 1,250 cases and 536 controls;
<italic>APOE</italic>
ε4-: 718 cases and 1,699 controls). Among
<italic>APOE</italic>
ε4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between
<italic>KANSL1</italic>
and
<italic>LRRC37A</italic>
on chromosome 17 near
<italic>MAPT</italic>
) in a meta-analysis of the stage 1 and stage 2 datasets (best SNP, rs2732703, P=5·8x10
<sup>−9</sup>
). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100 kilobase region that includes
<italic>MAPT</italic>
. Except for previously identified AD loci showing stronger association in
<italic>APOE</italic>
ε4+ subjects (
<italic>CR1</italic>
and
<italic>CLU</italic>
) or
<italic>APOE</italic>
ε4− subjects (
<italic>MS4A6A/MS4A4A/ MS4A6E</italic>
), no other SNPs were significantly associated with AD in a specific
<italic>APOE</italic>
genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of
<italic>APOE</italic>
with rs1595014 in
<italic>TMEM106B</italic>
(P=1·6x10
<sup>−7</sup>
) is noteworthy because
<italic>TMEM106B</italic>
variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four
<italic>KANSL1</italic>
probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3x10
<sup>−8</sup>
), frontal cortex (P≤1.3x10
<sup>−9</sup>
), and temporal cortex (P≤1.2x10
<sup>−11</sup>
). Rs113986870 is also strongly associated with a
<italic>MAPT</italic>
probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2x10
<sup>−6</sup>
) and temporal cortex (P=2.6x10
<sup>−6</sup>
). Our
<italic>APOE</italic>
-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking
<italic>APOE</italic>
ε4 compared to persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted.</p>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Gatz, M" uniqKey="Gatz M">M Gatz</name>
</author>
<author>
<name sortKey="Reynolds, Ca" uniqKey="Reynolds C">CA Reynolds</name>
</author>
<author>
<name sortKey="Fratiglioni, L" uniqKey="Fratiglioni L">L Fratiglioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Farrer, La" uniqKey="Farrer L">LA Farrer</name>
</author>
<author>
<name sortKey="Cupples, La" uniqKey="Cupples L">LA Cupples</name>
</author>
<author>
<name sortKey="Haines, Jl" uniqKey="Haines J">JL Haines</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sherva, R" uniqKey="Sherva R">R Sherva</name>
</author>
<author>
<name sortKey="Farrer, La" uniqKey="Farrer L">LA Farrer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lambert, J C" uniqKey="Lambert J">J-C Lambert</name>
</author>
<author>
<name sortKey="Ibrahim Verbaas, Ca" uniqKey="Ibrahim Verbaas C">CA Ibrahim-Verbaas</name>
</author>
<author>
<name sortKey="Harold, D" uniqKey="Harold D">D Harold</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jun, G" uniqKey="Jun G">G Jun</name>
</author>
<author>
<name sortKey="Vardarajan, Bn" uniqKey="Vardarajan B">BN Vardarajan</name>
</author>
<author>
<name sortKey="Buros, J" uniqKey="Buros J">J Buros</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trabzuni, D1" uniqKey="Trabzuni D">D1 Trabzuni</name>
</author>
<author>
<name sortKey="Ryten, M" uniqKey="Ryten M">M Ryten</name>
</author>
<author>
<name sortKey="Walker, R" uniqKey="Walker R">R Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Steinberg, Km" uniqKey="Steinberg K">KM Steinberg</name>
</author>
<author>
<name sortKey="Antonacci, F" uniqKey="Antonacci F">F Antonacci</name>
</author>
<author>
<name sortKey="Sudmant, Ph" uniqKey="Sudmant P">PH Sudmant</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Boettger, Lm" uniqKey="Boettger L">LM Boettger</name>
</author>
<author>
<name sortKey="Handsaker, Re" uniqKey="Handsaker R">RE Handsaker</name>
</author>
<author>
<name sortKey="Zody, Mc" uniqKey="Zody M">MC Zody</name>
</author>
<author>
<name sortKey="Mccarroll, Sa" uniqKey="Mccarroll S">SA McCarroll</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author>
<name sortKey="Wu, L" uniqKey="Wu L">L Wu</name>
</author>
<author>
<name sortKey="Corsa, Ca" uniqKey="Corsa C">CA Corsa</name>
</author>
<author>
<name sortKey="Kunkel, S" uniqKey="Kunkel S">S Kunkel</name>
</author>
<author>
<name sortKey="Dou, Y" uniqKey="Dou Y">Y Dou</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Koolen, Da" uniqKey="Koolen D">DA Koolen</name>
</author>
<author>
<name sortKey="Kramer, Jm" uniqKey="Kramer J">JM Kramer</name>
</author>
<author>
<name sortKey="Neveling, K" uniqKey="Neveling K">K Neveling</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Zollino, M" uniqKey="Zollino M">M Zollino</name>
</author>
<author>
<name sortKey="Orteschi, D" uniqKey="Orteschi D">D Orteschi</name>
</author>
<author>
<name sortKey="Murdolo, M" uniqKey="Murdolo M">M Murdolo</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Giannuzzi, G" uniqKey="Giannuzzi G">G Giannuzzi</name>
</author>
<author>
<name sortKey="Siswara, P" uniqKey="Siswara P">P Siswara</name>
</author>
<author>
<name sortKey="Malig, M" uniqKey="Malig M">M Malig</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Trabzuni, D" uniqKey="Trabzuni D">D Trabzuni</name>
</author>
<author>
<name sortKey="Wray, S" uniqKey="Wray S">S Wray</name>
</author>
<author>
<name sortKey="Vandrovcova, J" uniqKey="Vandrovcova J">J Vandrovcova</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Caffrey, Tm" uniqKey="Caffrey T">TM Caffrey</name>
</author>
<author>
<name sortKey="Joachim, C" uniqKey="Joachim C">C Joachim</name>
</author>
<author>
<name sortKey="Wade Martins, R" uniqKey="Wade Martins R">R Wade-Martins</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Sim N Sanchez, J" uniqKey="Sim N Sanchez J">J Simón-Sánchez</name>
</author>
<author>
<name sortKey="Schulte, C" uniqKey="Schulte C">C Schulte</name>
</author>
<author>
<name sortKey="Bras, Jm" uniqKey="Bras J">JM Bras</name>
</author>
</analytic>
</biblStruct>
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<analytic>
<author>
<name sortKey="Hoglinger, Gu" uniqKey="Hoglinger G">GU Höglinger</name>
</author>
<author>
<name sortKey="Melhem, Nm" uniqKey="Melhem N">NM Melhem</name>
</author>
<author>
<name sortKey="Dickson, Dw" uniqKey="Dickson D">DW Dickson</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name>
</author>
<author>
<name sortKey="Hardy, J" uniqKey="Hardy J">J Hardy</name>
</author>
<author>
<name sortKey="Momeni, P" uniqKey="Momeni P">P Momeni</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Coppola, G" uniqKey="Coppola G">G Coppola</name>
</author>
<author>
<name sortKey="Chinnathambi, S" uniqKey="Chinnathambi S">S Chinnathambi</name>
</author>
<author>
<name sortKey="Lee, Jj" uniqKey="Lee J">JJ Lee</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Lee, Se" uniqKey="Lee S">SE Lee</name>
</author>
<author>
<name sortKey="Tartaglia, Mc" uniqKey="Tartaglia M">MC Tartaglia</name>
</author>
<author>
<name sortKey="Yener, G" uniqKey="Yener G">G Yener</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ikram, Ma" uniqKey="Ikram M">MA Ikram</name>
</author>
<author>
<name sortKey="Fornage, M" uniqKey="Fornage M">M Fornage</name>
</author>
<author>
<name sortKey="Smith, Av" uniqKey="Smith A">AV Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Verpillat, P" uniqKey="Verpillat P">P Verpillat</name>
</author>
<author>
<name sortKey="Camuzat, A" uniqKey="Camuzat A">A Camuzat</name>
</author>
<author>
<name sortKey="Hannequin, D" uniqKey="Hannequin D">D Hannequin</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Zabetian, Cp" uniqKey="Zabetian C">CP Zabetian</name>
</author>
<author>
<name sortKey="Hutter, Cm" uniqKey="Hutter C">CM Hutter</name>
</author>
<author>
<name sortKey="Factor, Sa" uniqKey="Factor S">SA Factor</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Pittman, Am" uniqKey="Pittman A">AM Pittman</name>
</author>
<author>
<name sortKey="Myers, Aj" uniqKey="Myers A">AJ Myers</name>
</author>
<author>
<name sortKey="Abou Sleiman, P" uniqKey="Abou Sleiman P">P Abou-Sleiman</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Knopman, Ds1" uniqKey="Knopman D">DS1 Knopman</name>
</author>
<author>
<name sortKey="Petersen, Rc" uniqKey="Petersen R">RC Petersen</name>
</author>
<author>
<name sortKey="Edland, Sd" uniqKey="Edland S">SD Edland</name>
</author>
<author>
<name sortKey="Cha, Rh" uniqKey="Cha R">RH Cha</name>
</author>
<author>
<name sortKey="Rocca, Wa" uniqKey="Rocca W">WA Rocca</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Beecham, Gw" uniqKey="Beecham G">GW Beecham</name>
</author>
<author>
<name sortKey="Hamilton, K" uniqKey="Hamilton K">K Hamilton</name>
</author>
<author>
<name sortKey="Naj, A" uniqKey="Naj A">A Naj</name>
</author>
</analytic>
</biblStruct>
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<analytic>
<author>
<name sortKey="Myers, Aj" uniqKey="Myers A">AJ Myers</name>
</author>
<author>
<name sortKey="Kaleem, M" uniqKey="Kaleem M">M Kaleem</name>
</author>
<author>
<name sortKey="Marlowe, L" uniqKey="Marlowe L">L Marlowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Abraham, R" uniqKey="Abraham R">R Abraham</name>
</author>
<author>
<name sortKey="Sims, R" uniqKey="Sims R">R Sims</name>
</author>
<author>
<name sortKey="Carroll, L" uniqKey="Carroll L">L Carroll</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Creese, B" uniqKey="Creese B">B Creese</name>
</author>
<author>
<name sortKey="Corbett, A" uniqKey="Corbett A">A Corbett</name>
</author>
<author>
<name sortKey="Jones, E" uniqKey="Jones E">E Jones</name>
</author>
<author>
<name sortKey="Fox, C" uniqKey="Fox C">C Fox</name>
</author>
<author>
<name sortKey="Ballard, C" uniqKey="Ballard C">C Ballard</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Allen, M" uniqKey="Allen M">M Allen</name>
</author>
<author>
<name sortKey="Kachadoorian, M" uniqKey="Kachadoorian M">M Kachadoorian</name>
</author>
<author>
<name sortKey="Quicksall, Z" uniqKey="Quicksall Z">Z Quicksall</name>
</author>
</analytic>
</biblStruct>
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<analytic>
<author>
<name sortKey="Zody, Mc" uniqKey="Zody M">MC Zody</name>
</author>
<author>
<name sortKey="Jiang, Z" uniqKey="Jiang Z">Z Jiang</name>
</author>
<author>
<name sortKey="Fung, Hc" uniqKey="Fung H">HC Fung</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Trabzuni, D" uniqKey="Trabzuni D">D Trabzuni</name>
</author>
<author>
<name sortKey="Wray, S" uniqKey="Wray S">S Wray</name>
</author>
<author>
<name sortKey="Vandrovcova, J" uniqKey="Vandrovcova J">J Vandrovcova</name>
</author>
</analytic>
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<analytic>
<author>
<name sortKey="Zhong, Q" uniqKey="Zhong Q">Q Zhong</name>
</author>
<author>
<name sortKey="Congdon, Ee" uniqKey="Congdon E">EE Congdon</name>
</author>
<author>
<name sortKey="Nagaraja, Hn" uniqKey="Nagaraja H">HN Nagaraja</name>
</author>
<author>
<name sortKey="Kuret, J" uniqKey="Kuret J">J Kuret</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Krstic, D" uniqKey="Krstic D">D Krstic</name>
</author>
<author>
<name sortKey="Knuesel, I" uniqKey="Knuesel I">I Knuesel</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Laws, Sm" uniqKey="Laws S">SM Laws</name>
</author>
<author>
<name sortKey="Friedrich, P" uniqKey="Friedrich P">P Friedrich</name>
</author>
<author>
<name sortKey="Diehl Schmid, J" uniqKey="Diehl Schmid J">J Diehl-Schmid</name>
</author>
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<author>
<name sortKey="Roks, G" uniqKey="Roks G">G Roks</name>
</author>
<author>
<name sortKey="Dermaut, B" uniqKey="Dermaut B">B Dermaut</name>
</author>
<author>
<name sortKey="Heutink, P" uniqKey="Heutink P">P Heutink</name>
</author>
</analytic>
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<author>
<name sortKey="Cousin, E" uniqKey="Cousin E">E Cousin</name>
</author>
<author>
<name sortKey="Mace, S" uniqKey="Mace S">S Macé</name>
</author>
<author>
<name sortKey="Rocher, C" uniqKey="Rocher C">C Rocher</name>
</author>
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<author>
<name sortKey="Tesseur, I" uniqKey="Tesseur I">I Tesseur</name>
</author>
<author>
<name sortKey="Van Dorpe, J" uniqKey="Van Dorpe J">J Van Dorpe</name>
</author>
<author>
<name sortKey="Spittaels, K" uniqKey="Spittaels K">K Spittaels</name>
</author>
<author>
<name sortKey="Van Den Haute, C" uniqKey="Van Den Haute C">C Van den Haute</name>
</author>
<author>
<name sortKey="Moechars, D" uniqKey="Moechars D">D Moechars</name>
</author>
<author>
<name sortKey="Van Leuven, F" uniqKey="Van Leuven F">F Van Leuven</name>
</author>
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<author>
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</author>
<author>
<name sortKey="Kauwe, Js" uniqKey="Kauwe J">JS Kauwe</name>
</author>
<author>
<name sortKey="Harari, O" uniqKey="Harari O">O Harari</name>
</author>
</analytic>
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<name sortKey="Morris, Gp" uniqKey="Morris G">GP Morris</name>
</author>
<author>
<name sortKey="Clark, Ia" uniqKey="Clark I">IA Clark</name>
</author>
<author>
<name sortKey="Vissel, B" uniqKey="Vissel B">B Vissel</name>
</author>
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<author>
<name sortKey="Zuccolo, J" uniqKey="Zuccolo J">J Zuccolo</name>
</author>
<author>
<name sortKey="Bau, J" uniqKey="Bau J">J Bau</name>
</author>
<author>
<name sortKey="Childs, Sj" uniqKey="Childs S">SJ Childs</name>
</author>
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</author>
<author>
<name sortKey="Nowotny, P" uniqKey="Nowotny P">P Nowotny</name>
</author>
<author>
<name sortKey="Cady, J" uniqKey="Cady J">J Cady</name>
</author>
<author>
<name sortKey="Cruchaga, C" uniqKey="Cruchaga C">C Cruchaga</name>
</author>
<author>
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</author>
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</author>
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</author>
<author>
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</author>
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<author>
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<author>
<name sortKey="Fellerer, K" uniqKey="Fellerer K">K Fellerer</name>
</author>
<author>
<name sortKey="Schwenk, Bm" uniqKey="Schwenk B">BM Schwenk</name>
</author>
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<author>
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<author>
<name sortKey="Sleiman, Pm" uniqKey="Sleiman P">PM Sleiman</name>
</author>
<author>
<name sortKey="Martinez Lage, M" uniqKey="Martinez Lage M">M Martinez-Lage</name>
</author>
</analytic>
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<author>
<name sortKey="Vass, R" uniqKey="Vass R">R Vass</name>
</author>
<author>
<name sortKey="Ashbridge, E" uniqKey="Ashbridge E">E Ashbridge</name>
</author>
<author>
<name sortKey="Geser, F" uniqKey="Geser F">F Geser</name>
</author>
</analytic>
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<author>
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</author>
<author>
<name sortKey="Carrasquillo, Mm" uniqKey="Carrasquillo M">MM Carrasquillo</name>
</author>
<author>
<name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Cruchaga, C" uniqKey="Cruchaga C">C Cruchaga</name>
</author>
<author>
<name sortKey="Graff, C" uniqKey="Graff C">C Graff</name>
</author>
<author>
<name sortKey="Chiang, Hh" uniqKey="Chiang H">HH Chiang</name>
</author>
</analytic>
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<li>Allemagne</li>
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<li>Belgique</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Grèce</li>
<li>Irlande (pays)</li>
<li>Islande</li>
<li>Japon</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
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<li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Aquitaine</li>
<li>Arizona</li>
<li>Bavière</li>
<li>Catalogne</li>
<li>Communauté de Madrid</li>
<li>District de Cologne</li>
<li>District de Darmstadt</li>
<li>District de Haute-Bavière</li>
<li>Grand Londres</li>
<li>Haute-Normandie</li>
<li>Hauts-de-France</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
<li>Languedoc-Roussillon</li>
<li>Missouri (État)</li>
<li>Nord-Pas-de-Calais</li>
<li>Nottinghamshire</li>
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<li>Occitanie (région administrative)</li>
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<li>Québec</li>
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<li>Région flamande</li>
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<li>Lille</li>
<li>Londres</li>
<li>Madrid</li>
<li>Montpellier</li>
<li>Montréal</li>
<li>Munich</li>
<li>New York</li>
<li>Nottingham</li>
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<li>Paris</li>
<li>Pittsburgh</li>
<li>Rotterdam</li>
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<li>Université Columbia</li>
<li>Université Lille 2</li>
<li>Université Louis-et-Maximilien de Munich</li>
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<li>Université d'Oxford</li>
<li>Université de Cambridge</li>
<li>Université de Nottingham</li>
<li>Université de Pittsburgh</li>
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<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
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<name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name>
<name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name>
<name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name>
<name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name>
<name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name>
<name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<name sortKey="Kunkle, Brian W" sort="Kunkle, Brian W" uniqKey="Kunkle B" first="Brian W." last="Kunkle">Brian W. Kunkle</name>
<name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name>
<name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name>
<name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name>
<name sortKey="Wendland, Jens R" sort="Wendland, Jens R" uniqKey="Wendland J" first="Jens R." last="Wendland">Jens R. Wendland</name>
<name sortKey="Wilhelmsen, Kirk C" sort="Wilhelmsen, Kirk C" uniqKey="Wilhelmsen K" first="Kirk C." last="Wilhelmsen">Kirk C. Wilhelmsen</name>
<name sortKey="Winslow, Ashley R" sort="Winslow, Ashley R" uniqKey="Winslow A" first="Ashley R." last="Winslow">Ashley R. Winslow</name>
<name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name>
</country>
<country name="Pays-Bas">
<region name="Hollande-Méridionale">
<name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
</region>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name>
</noRegion>
<name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name>
<name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name>
<name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name>
<name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name>
<name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name>
<name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name>
<name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name>
<name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name>
<name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name>
<name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name>
<name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
<name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name>
<name sortKey="St George Hyslop, Peter H" sort="St George Hyslop, Peter H" uniqKey="St George Hyslop P" first="Peter H." last="St George-Hyslop">Peter H. St George-Hyslop</name>
<name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name>
</country>
<country name="France">
<region name="Hauts-de-France">
<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
</region>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name>
<name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name>
<name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name>
<name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name>
<name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<name sortKey="Hanon, Oliver" sort="Hanon, Oliver" uniqKey="Hanon O" first="Oliver" last="Hanon">Oliver Hanon</name>
<name sortKey="Hanon, Oliver" sort="Hanon, Oliver" uniqKey="Hanon O" first="Oliver" last="Hanon">Oliver Hanon</name>
<name sortKey="Kamatani, Yochiro" sort="Kamatani, Yochiro" uniqKey="Kamatani Y" first="Yochiro" last="Kamatani">Yochiro Kamatani</name>
<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name>
<name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name>
<name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
</country>
<country name="Irlande (pays)">
<noRegion>
<name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name>
</noRegion>
<name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name>
</country>
<country name="Islande">
<noRegion>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
</noRegion>
<name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name>
<name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<name sortKey="Jakobsd Ttir, J Hanna" sort="Jakobsd Ttir, J Hanna" uniqKey="Jakobsd Ttir J" first="J Hanna" last="Jakobsd Ttir">J Hanna Jakobsd Ttir</name>
<name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name>
<name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
</country>
<country name="Autriche">
<noRegion>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
</noRegion>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
</country>
<country name="Japon">
<noRegion>
<name sortKey="Kamatani, Yochiro" sort="Kamatani, Yochiro" uniqKey="Kamatani Y" first="Yochiro" last="Kamatani">Yochiro Kamatani</name>
</noRegion>
</country>
<country name="Espagne">
<region name="Catalogne">
<name sortKey="Laza, Agustin Ruiz" sort="Laza, Agustin Ruiz" uniqKey="Laza A" first="Agustin Ruiz" last="Laza">Agustin Ruiz Laza</name>
</region>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluis" last="Tárraga">Lluis Tárraga</name>
</country>
<country name="Allemagne">
<region name="Rhénanie-du-Nord-Westphalie">
<name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name>
</region>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name>
</country>
<country name="Grèce">
<noRegion>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
</noRegion>
</country>
<country name="Canada">
<region name="Ontario">
<name sortKey="St George Hyslop, Peter H" sort="St George Hyslop, Peter H" uniqKey="St George Hyslop P" first="Peter H." last="St George-Hyslop">Peter H. St George-Hyslop</name>
</region>
<name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
</country>
<country name="Belgique">
<noRegion>
<name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
</noRegion>
<name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000070 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000070 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:4573764
   |texte=   A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:25778476" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1
Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022